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E. Hoster

As seen in: Annals of Oncology
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Articles by E. Hoster

Reply to the letter to the editor ‘the clinical dilemma of grade 3 follicular lymphoma’ by Sorigue et al.

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By K. Koch, E. Hoster, W. Klapper, N. Schmitz
| Annals of Oncology Verified
As pointed out by Sorigue et al. [1] in their letter related to our work [2], follicular lymphoma (FL) grade 3A and 3B is managed in Europe to some extent differently to China and the United States. In their letter, Sorigue et al. emphasize that this setting of clinical borders is not evidence-based. We agree with this comment and like to add that these treatment recommendations were developed from historical classifications before the WHO classification in 2001 implemented grading of FL.
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Clinical, pathological and genetic features of follicular lymphoma grade 3A: a joint analysis of the German low-grade and high-grade lymphoma study groups GLSG and DSHNHL

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By K. Koch, M. Ziepert, M. Unterhalt, G. Ott, E. Hoster
| Annals of Oncology Verified
Background Histologically, follicular lymphoma (FL) grades 1, 2 and 3A are composed of two distinct cell types, centroblasts and centrocytes. FL grade 3B is composed only of centroblasts and has been shown to differ in immunophenotype and genetics from FL that contain centrocytes. We aimed to understand the pathogenetic and clinical relation between FL grade 3A to FL grade 1/2 on the one hand and FL grade 3B on the other hand.
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