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Abstract Microvessel density (MVD), assessed via histopathology, is a key indicator of angiogenesis in lung adenocarcinoma (ADC). This study aimed to develop and validate an artificial intelligence (AI) system based on computed tomography (CT) images for the noninvasive preoperative assessment of MVD in ADC. This retrospective study included 152 surgically resected ADC patients from center 1(internal cohort) and center 2 (external cohort).
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