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Highlights • Exclusion of clonal haematopoiesis variants increased the positive predictive value and specificity of MRD detection by 15% and 6% respectively. Background The incidence of esophageal adenocarcinoma (EAC) is rapidly rising and has a 5-year survival rate of <20%. Beyond TNM (tumor–node–metastasis) staging, no reliable risk stratification tools exist and no large-scale studies have profiled circulating tumor DNA (ctDNA) at relapse in EAC.
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