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1 Introduction Epidermolysis bullosa (EB) is a rare condition caused by genetic variation at autosomal loci. It is mainly characterized by pathological changes such as skin brittleness increase and other structural abnormalities. The clinical features including skin and mucous membrane blisters, erosion, repeated ulcers, scar formation and ultimately carcinoma (1), which mostly involve the skin, oral cavity, digestive system and urinary system.
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