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Keywords HCC molecular subtype liver cell lineages atezolizumab bevacizumab immunotherapy mechanisms of response and resistance Introduction Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and the fourth most lethal.1 Combination immunotherapy with atezolizumab and bevacizumab has become a new standard of care as the first-line therapy for unresectable HCC by demonstrating strong antitumor activity in an initial phase 1b study (GO30140)2 and subsequently superior...
Get full text access Log in, subscribe or purchase for full access. References 1. Sung, H ∙ Ferlay, J ∙ Siegel, RL ∙ et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin. 2021; 71:209-249 2. Zhu, H ∙ Ma, X ∙ Ye, T ∙ et al. Esophageal cancer in China: practice and research in the new era Int J Cancer. 2023; 152:1741-1751 3.
Josephine Bruin, a live Himalayan brown bear donated by alumni in 1961, was getting too big for her home in the Rally Committee chair’s backyard. So she was shipped off to the San Diego Zoo, and the Rally Committee began the search for a new mascot. They had a bear costume, purchased by the alumni, but no one to wear it. Enter Charles Dennis, an undergraduate student – who would later become a professor at UCLA – with no particular aspirations to be a mascot.
The Plaza Room at De Neve Hall is a modest space. With beige walls and floral carpets, it’s a banquet hall that could be anywhere. Except that it’s on UCLA’s campus. And to the hundreds of current and former Bruin rugby players who fill the hall, that means a lot. “We spent a lot of time digging the club out of a hole, and I’m happy to say that the program is in the black,” said Matthew “Freddy” Fredrickson, 2012 rugby club president and alumnus.
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