Seipin deficiency alters MAM-LD contacts and abolishes the nutrient-driven organelle remodeling in vivo in mice We previously demonstrated that Seipin localizes at the MAM (Combot et al, 2022; Guyard et al, 2022), prompting us to investigate here whether Seipin deficiency affects MAMs in AT. We analyzed subcutaneous AT from inducible adipocyte-specific Seipin-knockout mice (iATSKO) 15 days after tamoxifen injection, resulting in a 70% reduction in Bscl2 mRNA levels (Fig. EV1A).
