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Discussion Here, we characterize an HLA-A11-restricted TCR that recognizes a 10-mer peptide derived from the CT-RCC HERV-E that is selectively expressed in ccRCC and show for the first time that T cells transduced with this TCR acquire the ability to kill ccRCC tumors in vitro and in vivo. We also describe a GMP-compliant method for their large-scale ex vivo generation for clinical use.
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Alexander I. Malov 1,*, Evgeniya S. Sidkina 2 and Elena V. Cherkasova 3 1 N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, 20 Nikolsky Ave., 163020 Arkhangelsk, Russia 2 Geological Institute of the Russian Academy of Sciences, 7 bld. 1.
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