Chathura J. Gunasekara1, C. Anthony Scott1, Eleonora Laritsky1, Maria S. Baker1, Harry MacKay1, Jack D. Duryea1, Noah J. Kessler3, 4, Garrett Hellenthal2, Alexis C. Wood1, Kelly R. Hodges5, Manisha Gandhi5, Amy B. Hair6, Matt J. Silver3, Sophie E. Moore3, 4, Andrew M. Prentice3, Yumei Li7, 8, Rui Chen7, 8, Cristian Coarfa9Email author and Robert A. Waterland1, 8Email authorView ORCID ID profile Genome Biology201920:105 https://doi.org/10.1186/s13059-019-1708-1 © The Author(s).