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Articles by Elisa Gouvêa
Sarcopenia and sepsis fuel a self-perpetuating cycle of immunometabolism decline
Abstract Sepsis and sarcopenia are intertwined clinical challenges characterized by profound immunometabolic dysregulation. Traditionally viewed as a passive reservoir, skeletal muscle is now recognized as an active immunometabolic rheostat that dynamically influences systemic inflammation and homeostasis. This review synthesizes recent advances that redefine our understanding of muscle in critical illness, moving beyond simplistic views of catabolism to encompass complex adaptive strategies.
microGLYMPH: a conceptual translational roadmap for microdialysis‑based assessment of CSF–interstitial solute exchange in acquired brain injury
The glymphatic system facilitates cerebrospinal fluid (CSF)–interstitial fluid exchange and plays a key role in solute clearance and neurophysiological homeostasis. While dysfunction of this system has been shown in traumatic brain injury, stroke, meningitis, idiopathic normal pressure hydrocephalus and neurodegenerative diseases, direct measurement of glymphatic transport in humans remains elusive.
Beyond the bleed: complications after aneurysmal subarachnoid hemorrhage. Pathophysiology, clinical implications, and management strategies: a review - Critical Care
The rebleeding risk for ruptured, unsecured aneurysms is around 12%; most rebleeding occurs within 24 h [74]—acknowledging heterogeneity in the timing of aneurysm securement and definition of rebleeding. Elevated systolic blood pressure (SBP), particularly above 160 mmHg [74], poorer clinical (i.e., higher World Federation of Neurosurgical Societies (WFNS) and Hunt-Hess grades) and radiological grades, and aneurysm characteristics are associated with a higher risk [75, 76].
Haemoglobin values, transfusion practices, and long-term outcomes in critically ill patients with traumatic brain injury: a secondary analysis of CENTER-TBI | Critical Care | Full Text
The primary objective of this study was to evaluate whether haemoglobin values, from admission to the first week of ICU stay, were independently associated with long-term functional outcomes. Secondary objectives included the association of haemoglobin values with mortality and transfusion practices across countries. The CENTER-TBI study (NCT02210221) was a longitudinal, prospective observational study conducted across 65 centres in Europe and Israel.
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