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Ellen Donohoe

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Articles by Ellen Donohoe

miRNA cargo from pleural mesothelioma-derived extracellular vesicles reprograms fibroblasts toward an inflammatory CAF-like phenotype

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By Vivek Dharwal, Richard Zelei, Ali Azimi, Lucy Wang, Tim Huang, Ling Zhuang, Georges Emile Grau, Stephen Clarke, Steven C Kao, Fatemeh Vafaee, Zaklina Kovacevic, Elham Hosseini-Beheshti, Winston Lay, Ellen Donohoe
| Nature Verified
Abstract Pleural mesothelioma (PM) is an aggressive cancer with a low survival rate. A better understanding of disease pathogenesis can aid the development of therapies. This study profiles the miRNA cargo of PM-derived extracellular vesicles (EVs) and examines their effects on fibroblasts, the predominant cell type in the PM tumour microenvironment (TME).
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