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Articles by Ellen Forty
Targetingpyruvate kinase M2 isoform inhibits proliferation of human lung fibroblasts
AbstractBackground: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease of poor prognosis with a paucity of therapeutic options. Similarities between cancer cell biology and fibro-prolifortative pathomechanisms in fibrosis are becoming increasingly recognised, in particular the role of cell metabolism in driving these processes.Aims: A hallmark of certain tumours is their ability to anabolically fuel cell proliferation by aerobic glycolysis.
Metabolic shift during TGF-β induced collagen synthesis
Metabolic shift during TGF-? induced collagen synthesis Brintha Selvarajah, Ilan Azuelos, Ellen Forty, Manuela Plate, Dimitrios Anastasiou, Paul Mercer, Rachel Chambers QJM Sep 2016, 109 (suppl 1) S3; DOI: 10.1093/qjmed/hcw119.002
P112 Discovery of a Novel, High Affinity, Small Molecule αvβ6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis
P112 Discovery of a Novel, High Affinity, Small Molecule ?v?6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis Rob Slack, Alison John, Ellen Forty, Paul Mercer, Rebecca Graves, Tao Pun, Giovanni Vitulli, Elaine Gower, Valerie Morrison, Steve Ludbrook, Carmel Nanthakumar, Niall Anderson, Pan Procopiou, John Pritchard, David Budd, David Flint, Susan Pyne, Jane Denyer, John Marshall, Andrew Fisher, Rachel Chambers, Gisli Jenkins, Pauline Lukey, Simon Macdonald, Richard Marshall QJM...
P066 Targeting pyruvate kinase M2 isoform as common mechanism in tissue fibroblast proliferation
P066 Targeting pyruvate kinase M2 isoform as common mechanism in tissue fibroblast proliferation Ellen Forty, Paul Mercer, Dimitrios Anastasiou, Andy Blanchard, Rachel Chambers QJM Sep 2016, 109 (suppl 1) S44; DOI: 10.1093/qjmed/hcw124.040
mTOR regulates glucose metabolism during TGFβ-Induced fibroblast to myofibroblast differentiation
mTOR regulates glucose metabolism during TGF?-Induced fibroblast to myofibroblast differentiation Ilan Azuelos, Brintha Selvarajah, Ellen Forty, Manuela Plate, Gino Brunori, Lindsay Edwards, Andy Blanchard, Paul Mercer, Rachel Chambers QJM Sep 2016, 109 (suppl 1) S3-S4; DOI: 10.1093/qjmed/hcw119.003
Metabolic shift during TGF- β-induced collagen synthesis
Metabolic shift during TGF- ?-induced collagen synthesis Brintha Selvarajah, Ilan Azuelos, Ellen Forty, Manuela Plate, Dimitris Anastasiou, Paul Mercer, Rachel Chambers European Respiratory Journal Sep 2016, 48 (suppl 60) OA485; DOI: 10.1183/13993003.congress-2016.OA485
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