The U.S. Department of Health and Human Services (HHS) issued companion regulations advancing the interoperability of and patient access to electronic health information under the 21st Century Cures Act that will take effect June 30, 2020, with a compliance date of November 2, 2020. Now is the time to learn what the Information Blocking Rule will require and begin the work with stakeholders to establish new practices for advancing interoperability goals safely and securely.