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Abstract Background: Bone metastasis represents a major complication of advanced malignancies and is associated with substantial skeletal morbidity, impaired quality of life, and complex clinical decision-making. Artificial intelligence (AI) has rapidly emerged as an important computational approach for analyzing heterogeneous biomedical data.
Combined traumatic brain injury (CTBI) refers to traumatic brain injury (TBI) coexisting with significant extracranial injuries. Patients with this injury pattern typically present with life-threatening conditions such as shock and respiratory failure, require complex multidisciplinary management, and are at high risk of complications, as described in polytrauma cohorts that include TBI.
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