We conducted a retrospective analysis of prospectively collected data in consecutive adult patients admitted to the general ICU of an Italian tertiary university hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS (Rome), over a 10-year period between February 2012 and February 2022. Eligibility criteria were as follows: microbiologically confirmed IC, at least 2 serum BDG determinations within the ICU stay, availability of complete clinical and microbiological data.