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• There are dose-dependent plasma levels of E2730 in healthy rats during continuous infusion via osmotic pumps • Continuous infusion with E2730 results in no/minimal sedative or neuromotor adverse effects at antiseizure doses • Continuous infusion with E2730 results in strong seizure suppression in a model of chronic TLE 1 INTRODUCTION Epilepsy is a neurological disorder that is characterized by recurrent unprovoked seizures.
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