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Abstract Cancer generally takes years to evolve, and early diagnosis can prevent life-threatening cancer. Establishing a link between precancerous states and cancer is essential for effective screening and prevention. Esophageal adenocarcinoma (EAC) is an increasingly prevalent, poor-outcome cancer, and its presumed precursor, Barrett’s esophagus (BE), characterized by intestinal metaplasia, is evident in only about half of cases.
Methods A cohort was selected from a database of patients under BO surveillance at Addenbrooke’s Hospital (Cambridge University Hospitals NHS Foundation Trust) who consented prospectively to research participation. Strict selection criteria were applied to pathology, endoscopy and medical histories (online supplemental table S1). All oesophagogastroduodenoscopies (OGDs) comprised of multiple biopsies, each with known pathology.
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