Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Abstract The distribution of fitness effects (DFE) describes the proportion of new mutations with certain selective strengths. It is a crucial quantity for the study of complex disease and evolutionary genetics. Population genetics approaches infer the DFE using the site frequency spectrum (SFS), which summarizes allele frequencies within a sample.
Abstract The presence and impact of recessive lethal mutations has been widely documented in diploid outcrossing species. However, precise estimates in different species of the proportion of mutations that are recessive lethal remain limited. Here, we attempt to quantify the fraction of new mutations that are recessive lethal using Fit∂a∂i, a commonly-used method for inferring the distribution of fitness effects (DFE) using the site frequency spectrum.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
