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Abstract The coronavirus disease 2019 (COVID-19) pandemic has devastated families and disrupted healthcare, economies and societies across the globe. Molecular recognition agents that are specific for distinct viral proteins are critical components for rapid diagnostics and targeted therapeutics. In this work, we demonstrate the selection of novel DNA aptamers that bind to the SARS-CoV-2 spike glycoprotein with high specificity and affinity (<80 nM).
Identifying key barriers in cationic polymer gene delivery to human T cells Brynn R. Olden,a Emmeline Cheng,a Yilong Chenga and Suzie H. Pun*a Abstract T cells have emerged as a therapeutically-relevant target for ex vivo gene delivery and editing. However, most commercially available reagents cannot transfect T cells and designing cationic polymers for non-viral gene delivery to T cells has resulted in moderate success.
Identifying key barriers in cationic polymer gene delivery to human T cells Brynn Olden, Emmeline Cheng, Yilong Cheng and Suzie Pun Abstract T cells have emerged as a therapeutically-relevant target for ex vivo gene delivery and editing. However, most commercially available reagents cannot transfect T cells and designing cationic polymers for non-viral gene delivery to T cells has resulted in moderate success.
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