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Articles by En Ma
Ductile alloys offering 100 MPa tensile strength at 2,400 °C
Abstract Extreme applications call for materials that are not only strong to withstand thermomechanical loads at temperatures in excess of 2,000 °C (refs. 1,2,3), but also highly formable at room temperature to allow for processing into complex-shaped parts. The latter excludes brittle ceramics4 and intermetallic compounds5, limiting the selection to highly ductile metals and their alloys, but for them, an adequate strength at ultrahigh temperatures seems unreachable.
Hierarchical Twin Networks Enable Exceptional Strength and Fracture Toughness in Titanium
1 Introduction Hexagonal close-packed (HCP) metals such as titanium (Ti) are widely used in aerospace, marine, and biomedical applications, owing to their superior corrosion resistance, biocompatibility, and high specific yield strength (yield strength-to-density ratio) [1, 2].
Three-dimensional network of multi-fold twins enabled by geometrically necessary amorphous zones - Nature Communications
Abstract Three-dimensional multi-fold twin architectures are valuable for tailoring material properties but constructing them in man-made crystals remains challenging due to angular misfits from incomplete 360° space filling in large volumes, particularly lacking in-situ observations of crystal growth. Here, we successfully create three-dimensional architectures of plural multi-fold twins in a growing FeCoNiCuZn and the other multi-principal element alloy.
Key Structural Motifs Underlying the Unusual Deformation Flexibility and Phase‐Change Propensity in Amorphous Alloys
Conflict of Interest The authors declare no conflict of interest. References 1, Physical Metallurgy (Eds: D.E. Laughlin, K. Hono), Elsevier, Amsterdam, Netherlands, 2014, pp. 305–385. 2, , , MRS Bull. 2023, 48, 1054. 3, , , , , , , , , , , , , , Nat. Mater. 2024, 23, 1193. 4, , Phys. Rev. Lett. 2005, 95, 195501. 5, Sci. Adv. 2025, 11, aeb7908. 6, Nat. Mater. 2004, 3, 697. 7, , , , , Acta Mater. 2008, 56, 6264. 8, , , , , Nature 2006, 439, 419. 9, , , , , , , , Nat. Mater. 2011, 10, 28.
Unified theory of phonon in solids with phase diagram of non-Debye anomalies - Nature Physics
Abstract The classical Debye model successfully predicts phononic contribution to the specific heat of solids in the continuum limit. However, as the phonon wavenumber increases, their vibrational density of states gradually deviates from the Debye prediction and eventually manifests as Van Hove singularities for crystals and a boson peak for glasses. So far, there is still much controversy over whether these two non-Debye anomalies are equivalent or not.
Amorphous phase-change memory alloy with no resistance drift - Nature Materials
Abstract Spontaneous structural relaxation is intrinsic to glassy materials due to their metastable nature. For phase-change materials, the resultant temporal change in electrical resistance seriously hampers neuromorphic computing applications. Here we report an ab-initio-calculation-informed design of amorphous phase-change materials composed of robust ‘molecule-like’ motifs, depriving the amorphous alloy of critical structural ingredients responsible for relaxation and, hence, resistance drift.
Machine-learning design of ductile FeNiCoAlTa alloys with high strength
Now US embassies must vet students for ‘hostile attitudes’ but can resume visa appointments, State Department says CNN — The US State Department told embassies and consulates they must vet student visa applicants for “hostile attitudes towards our citizens, culture, government, institutions, or founding principles” but said they should resume appointments that were paused in late May.
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer
ApoE apolipoprotein E CM conditioned medium Co-IP/WB co-immunoprecipitation/western blot CXCR4 C-X-C chemokine receptor type 4 ERK1/2 extracellular signal-regulated kinase 1/2 GPCR G protein-coupled receptor LDLR low-density lipoprotein receptor LRP6 LDL receptor-related protein 6 SDF-1 stromal cell-derived factor 1 TNBC triple-negative breast cancer VLDLR very low-density lipoprotein receptor Introduction C-X-C chemokine receptor 4 (CXCR4) is a G protein-coupled receptor (GPCR) that is...
Baicalin Prevents Chronic β‐AR Agonist‐Induced Heart Failure via Preventing Oxidative Stress and Overactivation of the NADPH Oxidase NOX2
1 Introduction Heart failure (HF) remains the leading cause of mortality and morbidity worldwide, with a 5-year mortality rate of 50%–70%, and despite recent advancements in clinical treatment options, the number of people with HF has continued to increase [1, 2]. HF is characterised by a structural or functional abnormality of the heart that results in reduced cardiac output and/or elevated intracardiac pressure, ultimately leading to death [3].
Uncovering the Intrinsic High Fracture Toughness of Titanium via Lowered Oxygen Impurity Content
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202408286-sup-0001-SuppMat.docx7.5 MB Supporting Information adma202408286-sup-0002-MovieS1.mp48.1 MB Supplemental Movie 1 adma202408286-sup-0003-MovieS2.mp49.9 MB Supplemental Movie 2 References 1, Science 2010, 328, 319. 2, , , in Titanium Science and Technology, Metallurgical Society of AIME, vol. 2, Plenum Press, New York, NY 1973, pp. 1049–1069. 3, , ASTM Spec. Tech. Publ.
High-throughput screening to identify two-dimensional layered phase-change chalcogenides for embedded memory applications - npj Computational Materials
Abstract Chalcogenide phase-change materials (PCMs) are showing versatile possibilities in cutting-edge applications, including non-volatile memory, neuromorphic computing, and nano-photonics. However, for embedded phase-change memory applications, conventional PCMs suffer from insufficient thermal stability because of their relatively low crystallization temperatures (Tx).
Inward motion of diamond nanoparticles inside an iron crystal - Nature Communications
Abstract In the absence of externally applied mechanical loading, it would seem counterintuitive that a solid particle sitting on the surface of another solid could not only sink into the latter, but also continue its rigid-body motion towards the interior, reaching a depth as distant as thousands of times the particle diameter.
Inhibition of a novel Dickkopf-1-LDL receptor-related proteins 5 and 6 axis prevents diabetic cardiomyopathy in mice
Metabolic syndrome is commonly defined by the coexistence of high blood glucose, hypertension, and obesity and has become one of the most common and serious disorders worldwide due to increasing mortality and morbidity rates.1,2 Fatal cardiovascular complications constitute the most common outcomes of these health conditions, of which diabetic hypertension is thought to be the major risk factor.3 Unfortunately, high blood pressure is common in people with type 1 or type 2 diabetes (much more...
Device-scale atomistic modelling of phase-change memory materials - Nature Electronics
Abstract Computer simulations can play a central role in the understanding of phase-change materials and the development of advanced memory technologies. However, direct quantum-mechanical simulations are limited to simplified models containing a few hundred or thousand atoms.
Multiscale simulations of growth-dominated Sb2Te phase-change material for non-volatile photonic applications - npj Computational Materials
Abstract Chalcogenide phase-change materials (PCMs) are widely applied in electronic and photonic applications, such as non-volatile memory and neuro-inspired computing. Doped Sb2Te alloys are now gaining increasing attention for on-chip photonic applications, due to their growth-driven crystallization features. However, it remains unknown whether Sb2Te also forms a metastable crystalline phase upon nanoseconds crystallization in devices, similar to the case of nucleation-driven Ge-Sb-Te alloys.
Substantially enhanced homogeneous plastic flow in hierarchically nanodomained amorphous alloys - Nature Communications
Abstract To alleviate the mechanical instability of major shear bands in metallic glasses at room temperature, topologically heterogeneous structures were introduced to encourage the multiplication of mild shear bands. Different from the former attention on topological structures, here we present a compositional design approach to build nanoscale chemical heterogeneity to enhance homogeneous plastic flow upon both compression and tension.
An organic electrochemical transistor for multi-modal sensing, memory and processing - Nature Electronics
Abstract By integrating sensing, memory and processing functionalities, biological nervous systems are energy and area efficient. Emulating such capabilities in artificial systems is, however, challenging and is limited by the device heterogeneity of sensing and processing cores. Here we report an organic electrochemical transistor capable of sensing, memory and processing.
Babao Dan Alleviates Cancer Cachexia in Mice Via Inhibiting IL-6/STAT3 Signaling Pathway
Abstract Background: Cancer cachexia is a common but severe condition that causes muscle wasting, body weight loss, and progressive functional impairment, affecting over 50% of cancer patients. Currently, there are no effective treatments that can alleviate cachexia, and hence the discovery of new therapeutics that can effectively prevent or even reverse cancer cachexia is crucial.
Atomistic mechanism of phase transformation between topologically close-packed complex intermetallics - Nature Communications
Abstract Understanding how topologically close-packed phases (TCPs) transform between one another is one of the challenging puzzles in solid-state transformations. Here we use atomic-resolved tools to dissect the transition among TCPs, specifically the μ and P (or σ) phases in nickel-based superalloys. We discover that the P phase originates from intrinsic (110) faulted twin boundaries (FTB), which according to first-principles calculations is of extraordinarily low energy.
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