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Engineering Iby

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Articles by Engineering Iby

Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38‐Targeted Lipid Nanoparticles

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By Dana Tarab-Ravski, Engineering Iby, Aladar Fleischman Faculty, Inbal Hazan-Halevy
| Wiley Online Library Verified
Abstract Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable. RNA therapy delivered via lipid nanoparticles (LNPs) has the potential to be a promising cancer treatment, however, its clinical implementation is limited due to inefficient delivery to non-hepatic tissues.
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Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity - Scientific Reports

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By Ramat Aviv, Aladar Fleischman Faculty, Engineering Iby
| Nature Verified
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder and has no disease-modifying treatment yet. The hallmarks of AD are two amyloidogenic proteins: tau and amyloid β (Aβ). Tau undergoes several posttranslational modifications, including N-glycosylation. Tau was reported to be N-glycosylated in AD brains, but not in healthy counterparts, which may affect AD etiology. Here, we aimed to examine the effect of N-glycosylation on aggregation propensity of tau.
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