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Abstract Biochar is a promising amendment to promote cadmium (Cd) sorption and fixation in agricultural soil, where microplastics are emerging contaminants in soil. Herein, a greenhouse pot experiment was conducted to elucidate the effects on Cd availability in a soil–plant system by biochar and fresh/aged microplastics application.
Currently, 19 disease-modifying therapies (DMTs) have been approved for the treatment of patients with relapsing forms of multiple sclerosis (RMS). The objective of this study was to conduct a systematic review and network meta-analysis to evaluate the efficacy and safety of DMTs in adults with RMS.
Highlights • The increased number of RTX infusions was associated with prolonged B cell depletion. • The prolonged B cell depletion leads to decreased antibody production. • Absolute cell counts for T cells did not change over time. Abstract Background Rituximab (RTX) is a promising B-cell-depleting monoclonal antibody used to treat several autoimmune neurological diseases in children. The RTX administration regimen relies on the reconstitution of B cells in the peripheral blood.
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