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Eric Hillpot

As seen in: BioRxiv
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Articles by Eric Hillpot

SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice

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By Seyed A Biashad, Eric Hillpot, Francesco Morandini, Cheyenne Rechsteiner
| BioRxiv
Abstract SIRT6 is a protein deacylase, deacetylase, and mono-ADP-ribosylase (mADPr) regulating biological pathways important for longevity including DNA repair and silencing of LINE1 retrotransposons. SIRT6 knockout mice die by 30 days of age, whereas SIRT6 overexpression increases lifespan in male mice. Finding safe pharmacological activators of SIRT6 would have clinical benefits.
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Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle

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By Yang Zhao, Zhizhong Zheng, Zhihui Zhang, Eric Hillpot
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Susceptibility of epithelial cells cultured from different regions of human cervix to HPV16-induced immortalization

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By Han Deng, Eric Hillpot, Philomina Yeboah, Sumona Mondal
| PLOS
Persistent infection with high-risk human papillomavirus (HPV) is a major risk factor for cervical cancer. Greater than 90% of these cancers originate in the cervical transformation zone (TZ), a narrow region of metaplastic squamous epithelium that develops at the squamocolumnar junction between the ectocervix and endocervix. It is unclear why the TZ has high susceptibility to malignant transformation and few studies have specifically examined cells from this region.
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