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Articles by Eric J. Milliman
Identification of tofersen PD-response biomarkers in VALOR clinical trial CSF via multiplexed quantitative proteomics
Results Our CSF analysis included longitudinal CSF samples from 70 subjects enrolled in VALOR Part C7 with available material for all collection time points from baseline through week 16 (five time points). In line with the trial randomization (2:1 tofersen:placebo), our cohort consisted of 47 subjects in the tofersen treatment group and 23 subjects in the placebo arm (Figure 1A), which allowed us to randomly distribute subjects in a 2:1 ratio across 16-plex tandem mass tagged (TMT) sample sets.
Pharmacodynamic Effects of Litifilimab in Lupus in a Randomized, Placebo‐Controlled Phase 2 Study: Rapid and Sustained Reductions in Type I Interferon‐Associated Gene Expression and Cytokines
INTRODUCTION Systemic lupus erythematosus (SLE) is an inflammatory disease that affects multiple organs, with the musculoskeletal and mucocutaneous systems being most frequently involved.1-3 Cutaneous lupus erythematosus (CLE), which occurs with or without concomitant SLE, is categorized into chronic CLE (CCLE), subacute CLE (SCLE), or acute CLE subtypes.3 The interferon (IFN) family of cytokines include type I, type II, and type III IFNs and play an important role in the immune response...
Pharmacodynamic Effects of Litifilimab in Lupus in the LILAC Phase II Study: Rapid and Sustained Reductions in Type I Interferon‐Associated Gene Expression and Cytokines
Supporting Information Filename Description art43271-sup-0001-Disclosureform.pdfPDF document, 612.6 KB Disclosure Form art43271-sup-0002-Supinfo.zipZip archive, 2 MB Appendix S1: Supporting Information
The Loss of the H1.4 Linker Histone Impacts Nascent Transcription and Chromatin Accessibility
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Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells
Research Article | Spotlight Neah Likhite, Vikas Yadav, Eric J. Milliman, Danesh H. Sopariwala, Sabina Lorca, Nithya P. Narayana, Megha Sheth, Erin L. Reineke, Vincent Giguère, Vihang Narkar DOI: 10.1128/MCB.00411-18 ABSTRACT Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. However, their expression and function in the vasculature remains unknown.
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