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Articles by Eric S. Lightcap
CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade - Nature Communications
Abstract Serine/threonine kinase, cell division cycle 7 (CDC7) is critical for initiating DNA replication. TAK-931 is a specific CDC7 inhibitor, which is a next-generation replication stress (RS) inducer. This study preclinically investigates TAK-931 antitumor efficacy and immunity regulation. TAK-931 induce RS, generating senescence-like aneuploid cells, which highly expressed inflammatory cytokines and chemokines (senescence-associated secretory phenotype, SASP).
Ectopic activation of the miR-200c-EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy
Minggang Zhang https://orcid.org/0000-0002-0945-5736, Zeguo Zhao https://orcid.org/0000-0002-2901-5033, Yuri Pritykin https://orcid.org/0000-0001-6589-981X, Margaret Hannum, Andrew C. Scott https://orcid.org/0000-0002-3090-9704, Fengshen Kuo https://orcid.org/0000-0003-1797-2896, Viraj Sanghvi https://orcid.org/0000-0001-6526-7820, … Show All … , Timothy A.
A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
Eric S. Lightcap https://orcid.org/0000-0003-4825-3595 , Pengfei Yu https://orcid.org/0000-0002-3894-5697, Stephen Grossman, Keli Song, Mithun Khattar, Kristina Xega https://orcid.org/0000-0002-1932-3948, Xingyue He, … Show All … , James M. Gavin, Hisashi Imaichi https://orcid.org/0000-0002-2637-6685, James J.
Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia
Chitra Subramanian https://orcid.org/0000-0003-1101-5307, Matthew W. Frank https://orcid.org/0000-0002-4914-1440, Rajendra Tangallapally https://orcid.org/0000-0002-8727-2310, Mi-Kyung Yun https://orcid.org/0000-0003-1213-5714, Anne Edwards https://orcid.org/0000-0002-0692-2618, Stephen W. White https://orcid.org/0000-0001-8188-5944, Richard E. Lee https://orcid.org/0000-0002-2397-0443, Charles O.
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice
Jean-Christophe Delpech https://orcid.org/0000-0003-2674-1598, Dhruba Pathak, Merina Varghese https://orcid.org/0000-0002-1517-3903, Srinidhi Venkatesan Kalavai https://orcid.org/0000-0003-1888-0520, Emma C. Hays https://orcid.org/0000-0002-5526-2732, Patrick R. Hof https://orcid.org/0000-0002-3208-1154, W. Evan Johnson https://orcid.org/0000-0002-6247-6595, Seiko Ikezu, Maria Medalla https://orcid.org/0000-0003-4890-2532, Jennifer I.
Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors
Ling-juan Zhang https://orcid.org/0000-0001-6937-4578 , Christian F. Guerrero-Juarez https://orcid.org/0000-0002-6245-6412, Stella X. Chen https://orcid.org/0000-0002-3453-4786, Xiaowei Zhang https://orcid.org/0000-0002-7095-5326, Meimei Yin https://orcid.org/0000-0003-3718-1944, Fengwu Li https://orcid.org/0000-0001-5092-770X, Shuai Wu, … Show All … , Joyce Chen https://orcid.org/0000-0002-7317-7486, Min Li, Yingzi Liu https://orcid.org/0000-0002-8704-4756, Shang I. B. Jiang, Tissa Hata, Maksim V.
Unconventional interleukin-1β release suppresses antitumor immunity
Abstract Highlighted Article Abstract Inflammasome-independent release of IL-1β in the tumor microenvironment recruits T cell–suppressive neutrophils that support cancer progression. Interleukin-1 β (IL-1β) is a key driver of inflammation in different autoimmune and chronic inflammatory diseases. This is exemplified by the CANTOS trial that reported reduced recurrent cardiovascular events in patients that received anti–IL-1β antibodies.
Does protein aggregation drive postmitotic tissue degeneration?
Abstract REFERENCES AND NOTES Abstract Pharmacological evidence, from clinical trials where patients with systemic amyloid diseases are treated with disease-modifying therapies, supports the notion that protein aggregation drives tissue degeneration in these disorders. The protein aggregate structures driving tissue pathology and the commonalities in etiology between these diseases and Alzheimer’s disease are under investigation.
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography
Justin S. Sanchez https://orcid.org/0000-0003-4421-3078 , J. Alex Becker https://orcid.org/0000-0001-7435-1338, Heidi I. L. Jacobs https://orcid.org/0000-0001-7620-3822, Bernard J. Hanseeuw, Shu Jiang https://orcid.org/0000-0003-1464-4838, Aaron P. Schultz, Michael J. Properzi, … Show All … , Samantha R. Katz https://orcid.org/0000-0001-6048-7605, Alexa Beiser https://orcid.org/0000-0001-8551-7778, Claudia L.
ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma
Prateek Khanna https://orcid.org/0000-0002-7577-0101, Hong Jie Soh https://orcid.org/0000-0001-5489-1943, Chun-Hau Chen https://orcid.org/0000-0003-4301-6996, Ruchi Saxena https://orcid.org/0000-0002-9945-5384, Seema Amin, Maura Naughton https://orcid.org/0000-0002-3653-9310, Patrick Neset Joslin, … Show All … , Andrew Moore, Ziad Bakouny https://orcid.org/0000-0003-1906-5704, Carol O’Callaghan https://orcid.org/0000-0001-9328-5970, Paul Catalano https://orcid.org/0000-0002-1105-8852, Sabina...
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma
Raelene Endersby https://orcid.org/0000-0003-3554-2769 , Jacqueline Whitehouse, Allison Pribnow, Mani Kuchibhotla https://orcid.org/0000-0002-6348-4087, Hilary Hii https://orcid.org/0000-0002-8431-5725, Brooke Carline https://orcid.org/0000-0002-8061-4170, Suresh Gande, … Show All … , Jennifer Stripay https://orcid.org/0000-0002-0039-8675, Mathew Ancliffe, Meegan Howlett https://orcid.org/0000-0003-4332-6572, Tobias Schoep, Courtney George, Clara Andradas, Patrick Dyer, Marjolein Schluck...
The benefits of memory growing granular
Abstract Highlighted Article Abstract Brain imaging approaches show that the essential machinery for memory formation continues to develop into late childhood. We’ve all seen a preschool soccer team attempt to score a goal—a herd of tiny competitors slowed down by oversized shin guards that move down the field as a group. Adorable.
Could COVID-19 eliminate the alarm clock?
Abstract Highlighted Article Abstract Social restriction due to COVID-19 relieves social jet lag. Like our cave-dwelling ancestors, we maintain self-sustaining 24-hour behavioral oscillations termed circadian rhythms. Prominent among circadian behaviors is the human sleep-wake cycle.
Enhanced SARS-CoV-2 neutralization by dimeric IgA
Zijun Wang https://orcid.org/0000-0002-2095-2151, Julio C. C. Lorenzi https://orcid.org/0000-0003-2492-3961, Frauke Muecksch https://orcid.org/0000-0002-0132-5101, Shlomo Finkin https://orcid.org/0000-0003-4474-2658, Charlotte Viant, Christian Gaebler https://orcid.org/0000-0001-7295-8128, Melissa Cipolla https://orcid.org/0000-0001-8156-2512, … Show All … , Hans-Heinrich Hoffmann https://orcid.org/0000-0003-0554-0244, Thiago Y. Oliveira https://orcid.org/0000-0002-2654-0879, Deena A.
Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer
Emelie Foord https://orcid.org/0000-0002-4011-7401 , Lucas C. M. Arruda https://orcid.org/0000-0002-8573-9618, Ahmed Gaballa https://orcid.org/0000-0002-5277-5129, Charlotte Klynning, and Michael Uhlin https://orcid.org/0000-0002-2177-6727 An innate response to ovarian cancer Abstract Supplementary Material REFERENCES AND NOTES An innate response to ovarian cancer Favorable outcomes for patients with epithelial ovarian cancer have been associated with infiltration of immune cells into tumors.
In aged hosts, T cells turn traitorous
Abstract Highlighted Article Abstract Multimodal profiling of the aging immune system has identified highly abundant age–associated CD8+ T cells that home to organs and drive inflammation. A hallmark of aging is gradual immune dysfunction, leading to maladaptive inflammation termed “inflammaging” and impairment of immune responses that may contribute to increased incidence of diseases such as cancer in the elderly.
A QuICR test to diagnose Parkinson’s disease
Abstract Highlighted Article Abstract Refined conditions permit rapid detection of proteopathic α-synuclein seeds in cerebrospinal fluid from patients with Parkinson’s disease. Parkinson’s disease (PD) is one of several neurodegenerative diseases characterized by accumulation of fibrillar aggregates of α-synuclein (αSyn) protein, termed synucleinopathies.
Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth
Hannah C. Zierden https://orcid.org/0000-0002-4285-1618, Jairo I. Ortiz, Kevin DeLong, Jingqi Yu https://orcid.org/0000-0001-9012-0898, Gaoshan Li https://orcid.org/0000-0001-6809-0274, Peter Dimitrion, Sabrine Bensouda, … Show All … , Victoria Laney, Anna Bailey, Nicole M. Anders, Morgan Scardina, Mala Mahendroo, Sam Mesiano, Irina Burd, Gunter Wagner https://orcid.org/0000-0002-3097-002X, Justin Hanes https://orcid.org/0000-0001-9672-9821, and Laura M.
Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity
Xiangchen Gu https://orcid.org/0000-0003-1159-8565, Hongliu Yang https://orcid.org/0000-0001-5304-4777, Xin Sheng https://orcid.org/0000-0002-3620-3577, Yi-An Ko, Chengxiang Qiu https://orcid.org/0000-0002-6346-8669, Jihwan Park https://orcid.org/0000-0002-5728-912X, Shizheng Huang https://orcid.org/0000-0002-9240-1578, … Show All … , Rachel Kember https://orcid.org/0000-0001-8820-2659, Renae L. Judy, Joseph Park https://orcid.org/0000-0002-3313-641X, Scott M. Damrauer, Girish Nadkarni, Ruth J. F.
Probing the entire vascular system
Abstract Highlighted Article Abstract Microscopic endovascular probes that navigate by blood flow and an external magnetic field may increase the capabilities of vascular catheterization. Endovascular catheters are critical for medical practice, facilitating diagnostic and interventional procedures such as coronary arterial stenting or embolization of bleeding arteries. However, standard catheters are too large to navigate smaller or more tortuous blood vessels.
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
Victor Tkachev https://orcid.org/0000-0001-6011-0576 , James Kaminski https://orcid.org/0000-0002-5137-7516, E. Lake Potter https://orcid.org/0000-0003-4339-9800, Scott N. Furlan, Alison Yu, Daniel J.
Measurement of leukocyte trafficking kinetics in macaques by serial intravascular staining
E. Lake Potter https://orcid.org/0000-0003-4339-9800, Hannah P. Gideon https://orcid.org/0000-0002-4443-2134, Victor Tkachev https://orcid.org/0000-0001-6011-0576, Giulia Fabozzi, Alexander Chassiakos https://orcid.org/0000-0002-4871-4411, Constantinos Petrovas https://orcid.org/0000-0002-5067-5810, Patricia A. Darrah, Philana Ling Lin, Kathryn E. Foulds https://orcid.org/0000-0003-4418-6495, Leslie S. Kean https://orcid.org/0000-0003-0475-3926, JoAnne L.
The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer
Tino Vollmer https://orcid.org/0000-0002-0358-3876, Stephan Schlickeiser https://orcid.org/0000-0003-3142-2890, Leila Amini https://orcid.org/0000-0003-4855-5905, Sarah Schulenberg https://orcid.org/0000-0003-3719-6652, Desiree J. Wendering, Viqar Banday https://orcid.org/0000-0002-5081-2272, Anke Jurisch https://orcid.org/0000-0002-7794-1517, … Show All … , Rebecca Noster https://orcid.org/0000-0002-1069-0602, Desiree Kunkel https://orcid.org/0000-0002-0054-955X, Nicola R.
The microbiota in pneumonia: From protection to predisposition
Charlotte Thibeault https://orcid.org/0000-0002-8979-9386, Norbert Suttorp, and Bastian Opitz https://orcid.org/0000-0003-1276-836X Abstract REFERENCES AND NOTES Abstract Mucosal surfaces of the upper respiratory tract and gut are physiologically colonized with their own collection of microbes, the microbiota. The normal upper respiratory tract and gut microbiota protects against pneumonia by impeding colonization by potentially pathogenic bacteria and by regulating immune responses.
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
Marcos V. P. Gondim https://orcid.org/0000-0001-5636-9593, Scott Sherrill-Mix https://orcid.org/0000-0002-8955-8072, Frederic Bibollet-Ruche, Ronnie M. Russell https://orcid.org/0000-0003-1484-4207, Stephanie Trimboli, Andrew G. Smith, Yingying Li, … Show All … , Weimin Liu, Alexa N. Avitto https://orcid.org/0000-0003-1971-4479, Julia C. DeVoto, Jesse Connell https://orcid.org/0000-0002-9393-3074, Angharad E.
Targeting cartilage EGFR pathway for osteoarthritis treatment
Yulong Wei https://orcid.org/0000-0003-3823-9984, Lijun Luo, Tao Gui https://orcid.org/0000-0003-1892-4001, Feifan Yu, Lesan Yan https://orcid.org/0000-0003-3616-9628, Lutian Yao https://orcid.org/0000-0002-0652-2075, Leilei Zhong, … Show All … , Wei Yu https://orcid.org/0000-0001-6705-8264, Biao Han https://orcid.org/0000-0002-7812-3524, Jay M. Patel https://orcid.org/0000-0003-4889-0818, Jessica F.
Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol
Min Lu https://orcid.org/0000-0003-3397-3637, Shen Wang https://orcid.org/0000-0003-2245-070X, Tao Wang, Sisi Hu, Brijesh Bhayana, Momoko Ishii https://orcid.org/0000-0003-2839-5633, Yifei Kong, Yuchen Cai, Tianhong Dai https://orcid.org/0000-0001-8960-8896, Wenguo Cui https://orcid.org/0000-0002-6938-9582 , and Mei X.
Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer
Bianca Oresta https://orcid.org/0000-0002-4767-207X, Chiara Pozzi https://orcid.org/0000-0003-2153-6130, Daniele Braga https://orcid.org/0000-0003-2168-8425, Rodolfo Hurle, Massimo Lazzeri, Piergiuseppe Colombo, Nicola Frego, … Show All … , Marco Erreni https://orcid.org/0000-0002-1922-0818, Cristina Faccani, Grazia Elefante, Matteo Barcella https://orcid.org/0000-0002-2353-3999, Giorgio Guazzoni, and Maria Rescigno https://orcid.org/0000-0002-6464-509X Show Fewer A chemo drug’s immune side...
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide
Max Jan https://orcid.org/0000-0002-7071-5517, Irene Scarfò https://orcid.org/0000-0002-5545-3248, Rebecca C. Larson https://orcid.org/0000-0003-0174-061X, Amanda Walker, Andrea Schmidts https://orcid.org/0000-0001-7035-1584, Andrew A. Guirguis https://orcid.org/0000-0003-3134-0596, Jessica A. Gasser, … Show All … , Mikołaj Słabicki https://orcid.org/0000-0001-6317-9296, Amanda A. Bouffard, Ana P. Castano, Michael C. Kann, Maria L.
Necrotizing enterocolitis induces T lymphocyte-mediated injury in the developing mammalian brain
Qinjie Zhou https://orcid.org/0000-0002-1321-7490, Diego F. Niño https://orcid.org/0000-0001-7687-6920, Yukihiro Yamaguchi, Sanxia Wang, William B. Fulton https://orcid.org/0000-0002-5289-1621, Hongpeng Jia https://orcid.org/0000-0001-6783-7532, Peng Lu, … Show All … , Thomas Prindle Jr., David Pamies https://orcid.org/0000-0002-1224-573X, Meaghan Morris https://orcid.org/0000-0001-5340-148X, Liam L. Chen, Chhinder P. Sodhi , and David J.
Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism
Shin-Ichiro Miyashita https://orcid.org/0000-0002-4815-9323, Jie Zhang, Sicai Zhang, Charles B. Shoemaker https://orcid.org/0000-0001-9738-1361, and Min Dong https://orcid.org/0000-0002-1744-7293 Nontoxic botulinum for drug delivery Abstract Supplementary Material REFERENCES AND NOTES Nontoxic botulinum for drug delivery Botulism is a severe and potentially fatal disease characterized by muscle paralysis.
Neuronal delivery of antibodies has therapeutic effects in animal models of botulism
Patrick M. McNutt https://orcid.org/0000-0002-5703-4565, Edwin J. Vazquez-Cintron https://orcid.org/0000-0002-4397-3713, Luis Tenezaca https://orcid.org/0000-0002-2952-847X, Celinia A. Ondeck https://orcid.org/0000-0002-6437-3856, Kyle E. Kelly, Mark Mangkhalakhili https://orcid.org/0000-0002-4868-7476, James B. Machamer https://orcid.org/0000-0003-3532-8068, … Show All … , Christopher A. Angeles https://orcid.org/0000-0002-8160-0352, Elliot J.
CRISPR cuts disease course short in blood disorders
Abstract Highlighted Article Abstract Gene editing for sickle cell disease and β-thalassemia results in potential curative response. Sickle cell disease (SCD) and β-thalassemia originate from mutations in the hemoglobin gene and are among the most common hereditary diseases in the world. Their high frequency is believed to originate from a protective effect against malaria, a mosquito-borne infectious disease.
Unraveling the mysteries of microsatellite instability
Abstract Highlighted Article Abstract DNA polymerase proofreading and mismatch repair deficiency have different microsatellites signatures. Human cells have developed several enzymatic pathways to repair damaged DNA during DNA replication and recombination, such as DNA mismatch repair (MMR), which recognizes and repairs erroneous insertion, deletion, or misincorporation of bases, and DNA polymerase (encoded by POLE and POLD1), which proofreads each nucleotide and excises mismatched nucleotides.
A protein sandwich enables real-time in vivo biomarker measurement
Abstract Highlighted Article Abstract Biosensors allow rapid, accurate, continuous measurement of glucose and insulin in live rats. Tools that enable continuous measurement of circulating biomarkers in vivo have potential to transform personalized medicine and accurate delivery of therapy with minimal side effects, regardless of inter-patient pharmacokinetic and pharmacodynamic variability.
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
Wei Wang https://orcid.org/0000-0003-3144-0802, Yuxuan Zheng https://orcid.org/0000-0002-7407-5684, Shuhui Sun https://orcid.org/0000-0003-1051-4067, Wei Li https://orcid.org/0000-0002-4106-0937, Moshi Song, Qianzhao Ji, Zeming Wu, … Show All … , Zunpeng Liu, Yanling Fan, Feifei Liu, Jingyi Li https://orcid.org/0000-0002-3126-7889, Concepcion Rodriguez Esteban, Si Wang https://orcid.org/0000-0003-2431-0612, Qi Zhou https://orcid.org/0000-0002-6549-9362, Juan Carlos Izpisua Belmonte...
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