Abstract Objective To report the outcomes and cost–benefit analysis of preclosure povidone-iodine lavage (PrePIL) used to reduce the risk of infection following total hip replacement (THR) surgery. Study design Retrospective study. Animals One thousand six hundred ninety-nine dogs, 17 cats. Methods The medical records of 2213 consecutive THR cases were reviewed to determine the incidence of infection. The last 102 were treated with PrePIL using a commercially sourced 0.035% povidone-iodine solution.