Recently, Pätsi et al. reported a novel class of 5-aminothiazole-containing ligands of prolyl oligopeptidase (PREP) that affect α-synuclein aggregation, reactive oxygen species (ROS) production, and autophagy irrespective of their ability to inhibit its peptidase activity. (1) Previously, Kilpeläinen et al., studying a series of 5-aminooxazoles, also reported a discrepancy between the potency of these molecules as peptidase inhibitors and their action in cell-based assays.
