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Articles by Ethan Wan
Does size matter? A national analysis of patterns of adjuvant immunotherapy receipt and tumor size-dependent survival in pT3N0M0 clear cell renal cell carcinoma.
In November 2021, the US FDA approved pembrolizumab in the adjuvant setting for surgically resected clear cell renal cell carcinoma (ccRCC) at high-risk of recurrence, including small pT3a tumors. We hypothesized that this subgroup of small pT3a tumors have better outcomes and less benefit to adjuvant therapy than larger pT3 tumors. We herein investigate the patterns of adjuvant immunotherapy receipt and its effects on survival in pT3a ccRCC tumors stratified by tumor size.
Dopamine drives persistent remodelling of the maternal brain
Abstract Pregnancy and postpartum experiences represent transformative physiological states that impose lasting demands on the maternal body and brain, resulting in lifelong neural adaptations1,2,3,4,5,6. However, the precise molecular mechanisms that drive these persistent alterations remain poorly understood.
Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer
eLife assessment This is an important study that uses chromatin accessibility as a measure to determine the impact of neuronal activity on the state of chromatin regulatory elements in striatal neurons. The authors provide convincing evidence of how Pdyn gene expression is highly dependent on a distal regulatory genomic region both at basal and upon neuronal activation in this particular system, a mechanism conserved as well in human neuronal cells.
Temporally Specific Gene Expression and Chromatin Remodeling Programs Regulate a Conserved Pdyn Enhancer
Abstract Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function and guide enduring plasticity. Neuronal activation promotes expression of an immediate early gene (IEG) program comprised primarily of activity-dependent transcription factors, which are thought to regulate a second set of late response genes (LRGs).
Temporally Specific Gene Expression and Chromatin Remodeling Programs Regulate a Conserved Pdyn Enhancer
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Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
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