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Background GC-biased gene conversion (gBGC) is a recombination-associated process that fixes G/C over A/T alleles irrespective of their effect on the protein and is a known cause of false positive-selection signals in molecular-evolution analyses. Examples of gBGC caught fixing a protein-altering change at a specific, conserved coding element, and generating a spurious selection signal in the process, remain rare.
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