This paper is only available as a PDF. To read, Please Download here. ABSTRACT Background & Aims In upper airway cells, Th2 cytokines that signal through IL-4 receptor alpha (IL4Rα) have been shown to stimulate eotaxin-3 secretion via a non-gastric proton pump (ngH +,K +ATPase). To seek novel targets for eosinophilic esophagitis (EoE) treatments, we evaluated ngH +,K +ATPase expression in EoE squamous cells, and explored molecular pathways involved in eotaxin-3 secretion by IL4Rα signaling.
