Introduction Facial composite tissue allotransplantation is an emerging treatment for patients with severe facial defects. Despite its promise, rejection remains a significant challenge because of the high immunogenicity of donor skin. In fact, acute rejection affects nearly all facial composite tissue allotransplantation recipients within the first postoperative year. 1 Morelon E. Petruzzo P. Kanitakis J. Chronic rejection in vascularized composite allotransplantation. Curr Opin Organ Transplant.
