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The prevalence of diabetes has reached 8.8% in worldwide population and is predicted to increase up to 10,4% by 2040. Thus, there is an urgent need for the development of means to treat or prevent this major disease. Due to its role in inflammatory responses, several studies demonstrated the importance of the transcription factor NF-κB in both type 1 (T1D) and type 2 diabetes (T2D). The two major NF-κB pathways are the canonical and the non-canonical.
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