Abstract Objectives: Surveillance of antimicrobial susceptibility patterns is essential for guiding effective therapy. This study aimed to evaluate the in vitro activity of ceftazidime-avibactam against Enterobacterales stratified by resistance phenotype. Material and Methods: This retrospective, laboratory-based surveillance study was conducted from 1st February to 30th November 2023 at the National Institute of Cardiovascular Diseases, a tertiary care cardiac centre in Karachi, Pakistan.