INTRODUCTION There is increasing evidence that autoinflammation plays an important role in the pathogenesis of myelodysplastic syndromes (MDS), with several studies describing dysregulation of the innate immune response, as being particularly relevant.1 For example, Toll-like receptors (TLRs) have been shown to be over-expressed in haematopoietic stem/progenitor cells (HSPCs), compared to age-matched control subjects.2 Furthermore, in the HSPCs of MDS patients, there is enhanced activation of...
