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Federica Fermani

As seen in: Science Magazine, BioRxiv
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Articles by Federica Fermani

Food and water uptake are regulated by distinct central amygdala circuits revealed using intersectional genetics

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By Federica Fermani, Simon Chang, Christian Peters, Louise Gaitanos
| BioRxiv
Abstract The central amygdala (CeA) plays a crucial role in defensive and appetitive behaviours. It contains genetically defined GABAergic neuron subpopulations distributed over three anatomical subregions, capsular (CeC), lateral (CeL), and medial (CeM). The roles that these molecularly- and anatomically- defined CeA neurons play in appetitive behavior remain unclear. Using intersectional genetics, we found that neurons driving food or water consumption are confined to the CeM.
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Molecular and neural mechanisms of behavioural integration in the extended-amygdala

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By Simon Chang, Federica Fermani, Lianyun Huang, Steffen Schneider
| BioRxiv
Abstract Integration of diverse stimuli is crucial for organisms to adapt and communicate effectively, enabling overall homeostasis and survival. Studies have been performed on identifying specific neuronal encoding of individual behaviours, but how neurons integrate diverse behaviours across contexts remains elusive. Here we use Ca2+ imaging in freely moving mice to identify neural ensembles in the extended amygdala encoding behaviours across six distinct contexts.
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Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior

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By Jinghao Lu, Quentin Dietschi, Simon Chang, Federica Fermani
| Science Magazine Verified
LATEST NEWS Abstract An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin-releasing hormone (CRH) neurons in the lateral part of the interstitial nucleus of the anterior commissure (IPACL), a subdivision of the extended amygdala, which exclusively innervate the substantia nigra (SN).
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