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Articles by Femke Simmer
Tumour deposits are associated with increased metastatic risk in colorectal cancer: a population-based analysis of metastatic patterns and burden
CI confidence interval CRC colorectal cancer EMT epithelial–mesenchymal transition HR hazard ratio LNM lymph node metastases NCR Netherlands Cancer Registry NOS not otherwise specified TD tumour deposits TME tumour microenvironment VIF variance inflation factor Introduction Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide.
Tumor deposits should not be placed in the M category of TNM: A comparative survival analysis using SEER data
1 INTRODUCTION The spread of tumor cells beyond the primary origin is the main cause of cancer-related death across various cancer types.1 In colorectal carcinoma (CRC) patients, tumor deposits (TD) are a well-recognized independent poor prognostic marker, which have been defined as discontinuous tumor nodules in the lymphatic drainage area of the pericolorectal region.2, 3 Although discussions are ongoing about exact definitions and placing, TD are currently staged within the N category of...
Appraisal of the PathoDiscovery: an interactive web‐based educational tool for teaching pathophysiology and histopathology
Abstract Virtual pathology education has shown to enhance the students' learning experience. At the Radboud University, an E-learning platform—called the “PathoDiscovery”—was developed and first used in a course about neoplasm development amongst first year (bio)medical sciences students.
Multifocal colorectal cancer - Do intraluminal metastases occur?
Femke Simmer Femke Simmer Correspondence Correspondence: Femke Doubrava-Simmer, Dept. of Pathology (824), Radboudumc, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, , Telephone: +31 (0)24 3618945, Fax: +31 (0)24 3668750 Affiliations Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboudumc. Nijmegen, the Netherlands Search for articles by this author Ragna LA. van der Linden Ragna LA.
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Abstract Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined.
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