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Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence Gimano D. Amatngalim, Jasmijn A. Schrumpf, Fernanda Dishchekenian, Tinne C.J. Mertens, Dennis K. Ninaber, Abraham C. van der Linden, Charles Pilette, Christian Taube, Pieter S. Hiemstra, Anne M. van der Does European Respiratory Journal Apr 2018, 51 (4) 1701009; DOI: 10.1183/13993003.01009-2017
AbstractResearch question: It is currently unknown how cigarette smoke-induced airway remodelling affects highly expressed respiratory epithelial defence proteins and thereby mucosal host defence.Methods: Localization of a selected set of highly expressed respiratory epithelial host defence proteins was assessed in well-differentiated primary bronchial epithelial cell (PBEC) cultures.
Aberrant airway epithelial differentiation resulting from cigarette smoke exposure leads to loss of constitutive antimicrobial peptide and protein (AMP) expression Pieter S. Hiemstra, Gimano D. Amatngalim, Jasmijn A. Schrumpf, Fernanda Dishchekenian, Tinne C.J. Mertens, Dennis K. Ninaber, Abraham C. van der Linden, Christian Taube, Anne M. van der Does European Respiratory Journal Sep 2016, 48 (suppl 60) PA1819; DOI: 10.1183/13993003.congress-2016.PA1819
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