1 Introduction Pulmonary artery hypertension (PAH) is caused by a progressive increase in pulmonary vascular resistance that results in adverse right ventricular remodeling, dysfunction, and heart failure (Bernardo et al., 2020; Zolty, 2020; Humbert et al., 2022). As the disease progresses, the stability of cardiac pump and right ventricular function is impaired (Benoist et al., 2012; Fowler et al., 2015), making it difficult to manage the increased contractile demands.
