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3.2. Parkinson’s Disease (PD) Parkinson’s disease is the second most common neurodegenerative disorder. The main pathological hallmarks of Parkinson’s disease are intracellular inclusions that contain aggregates of α-synuclein (Lewy bodies), striatal dopamine deficiency, and loss of dopaminergic neurons in the substantia nigra. The motor symptoms of Parkinson’s disease in patients include the presence of bradykinesia, rigidity, and resting tremor.
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