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Articles by Frank Breve
Psychedelics and Ibogaine “Pain Medications” at the Pharmacy Counter: Implications for Pharmacy Practice
Back to Journals » Journal of Pain Research » Volume 19 Authors Breve F, Berenato FJ, Pergolizzi JV Jr, Varrassi G , Raffa RB Received 2 June 2026 Accepted for publication 26 June 2026 Published 8 July 2026 Volume 2026:19 629049 DOI https://doi.org/10.2147/JPR.S629049 Checked for plagiarism Yes Editor who approved publication: Dr Robert Twillman Frank Breve,1 Frank J Berenato,2 Joseph V Pergolizzi Jr,3,4 Giustino Varrassi,5 Robert B Raffa3,6 1Clinical Pharmacy, Mid Atlantic PharmaTech...
Cychlorphine ( N -Propionitrile Chlorphine): An Emerging Benzimidazolone Synthetic Opioid and Its Implications for Overdose Recognition and Management
Back to Journals » Journal of Pain Research » Volume 19 Editorial Opioids and Substance Abuse Authors Raffa RB , Breve F, Pergolizzi JV Jr, Vortsman E, Varrassi G Received 1 May 2026 Accepted for publication 28 June 2026 Published 10 July 2026 Volume 2026:19 620907 DOI https://doi.org/10.2147/JPR.S620907 Checked for plagiarism Yes Editor who approved publication: Dr Timothy Atkinson Robert B Raffa,1,2 Frank Breve,3 Joseph V Pergolizzi Jr,2,4 Eugene Vortsman,5 Giustino Varrassi6 1School of...
Controlled Substance Waste: Concerns, Controversies, Solutions
Diversion concerns While controlled substance diversion exists in the healthcare system, it has been challenging to objectively quantify [8,9]. This is exemplified by the fact that no one knows the true extent of drug diversion; estimates indicate that 10% or more of healthcare professionals have diverted controlled substances [10]. Thus, it has been difficult to issue definitive guidance in terms of how to prevent it [11].
Considering tapentadol as a first-line analgesic: 14 questions
Tapentadol is the newest centrally acting analgesic to be approved by the US FDA and regulatory bodies in other countries. It has been called the first-in-class of a novel-acting analgesic mechanism of action that combines Â?-opioid receptor agonist activity with neuronal norepinephrine-reuptake inhibition in a single molecule.
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