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Articles by Freda Scheffler
Cortical morphometry might predict currently prescribed vs. discontinued medications in bipolar disorder, even after controlling for the cumulative dose effects: An ENIGMA mega-analysis
Abstract Recent research suggests that brain anatomy may help identify the most effective pharmacological treatment for each individual with bipolar disorder and reduce trial-and-error prescribing. We aimed to investigate whether brain anatomy predicts whether a medication is currently prescribed or has been discontinued, as a proxy for treatment effectiveness.
Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis - Molecular Psychiatry
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Abstract MRI studies in bipolar disorder (BD) have yielded inconsistent findings, partly due to the varied use of psychotropic medications. This study utilised a mega-analysis approach, accounting for concurrent medication status (syndrome-based and Neuroscience-based Nomenclature (NbN) classifications), in order to assess the association of medication status with subcortical brain volumes in BD.
By Joaquim Radua, Brian Hallahan, Christoph Abe, Dag Alnæs, Silvia Amoretti, Jochen Bauer, Francesco Benedetti, Michael Berk, Erlend Bøen, Joscha Böhnlein, Beatrice Bravi, Udo Dannlowski, Caroline Demro, Torbjørn Elvsåshagen, Maria Forte, Janice M. Fullerton, David Glahn, Benjamin I. Goldstein, Ian H. Gotlib, Roberto Goya-Maldonado, Melissa Green, Dominik Grotegerd, Tim Hahn Verified, Tomas Hajek, Josselin Houenou, Fleur M Howells, Kody G. Kennedy, Tilo Kircher, Anna Luisa Klahn, Maximilian Konowski, Rayus Kuplicki, Mikael Landén, Bradley J. MacIntosh, Hannah Meinert, Susanne Meinert, Philip Mitchell, Igor Nenadic, Bronwyn Overs, Nadine Green Parker, Godfrey Pearlson, James J. Prisciandaro, Yann Quidé, Amanda L. Rodrigue, Amanda Bautista Rodrígue, Fabio Sambataro, Jonathan Savitz, Freda Scheffler, Kang Hee Sim, Jair C. Soares, Aleix Solanes, Scott R. Sponheim, Dan Stein, Frederike Stein, Sophia I. Thomopoulos, Eduard Vieta, Lars T. Westlye, Daniel Wolf, Mon-Ju Wu, Dara M. Cannon, Ole A. Andreassen, Colm McDonald, Sinead King, Márcio Gerhardt Soeiro-de-Souza
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Nature
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Evaluating analytic strategies to obtain high-resolution, vertex-level measures of cortical neuroanatomy in children in low- and middle-income countries | Communications Biology
Abstract High-field magnetic resonance imaging to explore brain structure and function remains limited to high-resource settings. Novel, low-field (<0.1 T) imaging offers a more cost-effective/accessible alternative. However, the validity of low-field data at spatial resolutions relevant to research and clinic (vertex-level) remains unclear.
INVESTIGATING TRAIT IMPULSIVITY IN OBSESSIVE-COMPULSIVE DISORDER: A SCOPING REVIEW
The authors have declared no competing interest. This review was made possible (in part) by a grant from Carnegie Corporation of New York (MJB, grant number G-21-58838). The statements made and views expressed are solely the responsibility of the author. CL and DJS are supported by the SAMRC. SRC and CL receive a stipend from Elsevier for journal editorial work.
Mega‐analysis of the brain‐age gap in substance use disorder: An ENIGMA Addiction working group study
INTRODUCTION Considerable research has recently been undertaken on brain-based markers of aging. Brain age estimation uses machine learning by training and testing a model on large training and test datasets, then using this model to predict an individual's brain age in an independent dataset [1]. The most frequently used outcome of interest is the difference between an individual's model-predicted brain age and their chronological age (i.e. the brain age gap [BAG]).
Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses - Molecular Psychiatry
Abstract Converging evidence suggests that schizophrenia (SZ) with primary, enduring negative symptoms (i.e., Deficit SZ (DSZ)) represents a distinct entity within the SZ spectrum while the neurobiological underpinnings remain undetermined.
The associations of cannabis and methamphetamine use with cognitive performance over the first 2 years of treatment in schizophrenia spectrum disorders - Scheffler - - Early Intervention in Psychiatry - Wiley Online Library
ORIGINAL ARTICLE Freda Scheffler, Corresponding Author Freda Scheffler fredas@sun.ac.za orcid.org/0000-0002-8898-8599 Department of Psychiatry, Stellenbosch University, Cape Town, South Africa Correspondence Freda Scheffler, Department of Psychiatry, Faculty of Medicine and Health Sciences, PO Box 241, Cape Town, 8000, South Africa.
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