1. Introduction Osteoarthritis (OA) is a cartilage degenerative disease that affects both humans and animals. In horses, OA is a major cause of lameness and inevitably leads to decreased joint functions, animal welfare concerns, and increased risk of injury [1]. OA can occur due to aging, although this disease is also associated with athletic activity and can affect horses of any age, prematurely ending their sporting career and resulting in tremendous economic consequences.