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Fujin Yang

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Articles by Fujin Yang

Cimifugin ameliorates atopic dermatitis through modulation of the OGT/IL-4 axis and suppression of O-GlcNAcylation and downregulate IL-4

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By Xue Jiang, Deming Liu, Xi Chen, Fujin Yang
| Nature Verified
Abstract Atopic dermatitis (AD) is a prevalent inflammatory skin disorder where interleukin-4 (IL-4) plays a central pathogenic role. The post-translational modification O-GlcNAcylation, catalyzed by O-GlcNAc transferase (OGT), regulates protein stability and function, but its involvement in AD is unclear. This study aimed to investigate whether cimifugin, a natural chromone, alleviates AD by targeting the OGT/IL-4 axis.
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Topical Application of Fluoxetine Improves DNCB‐Induced Atopic Dermatitis in Mice

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By Xue Jiang, Xiaobin Wu, Children Chongqing, Fujin Yang
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. References 1, , and , “The Translational Revolution and Use of Biologics in Patients With Inflammatory Skin Diseases,” Journal of Allergy and Clinical Immunology 135, no. 2 (2015): 324–336. 2, , , et al., “Patient Burden of Moderate to Severe Atopic Dermatitis (AD): Insights From a Phase 2b Clinical Trial of Dupilumab in Adults,” Journal of the American Academy of Dermatology 74, no. 3 (2016): 491–498.
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