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Fuxue Xing

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Articles by Fuxue Xing

Disrupting the NAD + /NAM metabolic ratio driven by IL-1β inflammatory response potentiates chemotherapy and chemoimmunotherapy in mice

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By Fuxue Xing, Hongwei Lv, Liang Wang, Yun Feng, Wei Xiang, Lu Wu, Guoqing Jiang, Yue Ma, Xiaoyan Sun, Zixin Wu, Qiuyu Lu, Min Zhang, Qianni Zong, Guishuai Lv, Chunying Liu, Qiyu Feng, Hongyang Wang, Kunqing Xiao
| Nature Verified
Abstract Nicotinamide adenine dinucleotide (NAD+) replenishment sensitizes tumors to immunotherapy. However, chemotherapy-induced NAD+ metabolic reprogramming remains poorly understood. Here, we show that chemotherapy induces a macrophage-dependent IL-1β inflammatory response and NAD+ metabolic reprogramming, thereby conferring chemoresistance via CD44.
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