Previous work in our lab has demonstrated that BPA exposure impairs spatial memory and hippocampal dendritic spine formation through Wnt signaling pathway in SD male rats4. While, there are still some major questions remaining to be clarified. As a xenoestrogen chemical, whether the effect of BPA on spatial memory is sex-specific? Whether BPA impaired spatial memory by altering the network and neuronal connection in hippocampus? Whether and how BPA influences synaptic transmission?
