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Author notes Quentin Bertrand Present address: Laboratory of Biomolecular Research, Biology and Chemistry Division, Paul Scherrer Institute, Villigen, Switzerland Authors and Affiliations School of Biology, University of St Andrews, St Andrews, UK Gaëlle Hogrel, Shirley Graham, Hannah Rickman, Sabine Grüschow & Malcolm F.
Abstract Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS–STING innate immunity pathway1, which originated in bacteria2.
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