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Citric acid treatment significantly disrupted human leucocyte antigen (HLA) Class I antigens, and this disruption was maintained during platelet storage. HLA-disrupted platelets retained their ability to aggregate and form clots over storage despite increased activation and platelet loss. With further development, HLA-disrupted platelet components may be used to support transfusion needs when HLA-compatible components are unavailable.
Mycoplasma pneumoniae is a common respiratory pathogen which may cause haematological manifestations including haemolytic anaemia and thrombocytopaenia. Severe neutropaenia is rare with very few cases reported in the literature. An 85-year-old man was transferred to our facility with agranulocytosis in the context of an infective exacerbation of chronic obstructive pulmonary disease with positive serological testing for M. pneumoniae.
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