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In order to increase understanding of how T3 induces hypertrophy and/or terminal maturation and how these processes mark OA pathophysiology, we performed cartilage RNA-seq analysis of control and T3 treated human osteochondral explants that were harvested from total knee replacement surgery material. The dataset consisted of 16 paired cartilage samples from 8 donors, 6 males and 2 females and with an average age of 69.9 years (range 59-76).
Phenotypic assays using human primary cells are highly valuable tools for target discovery and validation in drug discovery. Expression knockdown (KD) of such targets in these assays allows the investigation of their role in models of disease processes. Therefore, efficient and fast modes of protein KD in phenotypic assays are required. The CRISPR/Cas9 system has been shown to be a versatile and efficient means of gene inactivation in immortalized cell lines.
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