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Articles by Gan Jiang
Self-assembling scaffolds epigenetically reactivate and electroactively guide neuronal regeneration to restore central neural circuits
Abstract Central nervous system (CNS) injury is a leading cause of death and long-term disability worldwide. Neurological deficits reflect disruption of central neural circuits. A major barrier to circuit repair is the intrinsically low regenerative potential of adult CNS neurons—linked in part to failure of injury-induced nuclear export of class IIa histone deacetylases (notably HDAC5)—together with a hostile post-injury microenvironment.
Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function - Nature Nanotechnology
Abstract Nanoparticles (NPs) represent an important advance for delivering diagnostic and therapeutic agents across the blood–brain barrier. However, NP clearance is critical for safety and therapeutic applicability. Here we report on a study of the clearance of model organic and inorganic NPs from the brain. We find that microglial extracellular vesicles (EVs) play a crucial role in the clearance of inorganic and organic NPs from the brain.
Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma - Nature Communications
Abstract The limited benefits of immunotherapy against glioblastoma (GBM) is closely related to the paucity of T cells in brain tumor bed. Both systemic and local immunosuppression contribute to the deficiency of tumor-infiltrating T cells. However, the current studies focus heavily on the local immunosuppressive tumor microenvironment but not on the co-existence of systemic immunosuppression.
Airborne Sound Sensing System Based on DAS and Ultra-Simple Transducer Structure
Open AccessCommunication by Jianfang Tang 1, Minghao Hu 2, Gan Jiang 2, Xuanyu Zheng 2 and Fei Peng 2,* 1 CGN New Energy Holding Co., Ltd., Beijing 100071, China 2 College of Electrical Engineering, Sichuan University, Chengdu 610065, China * Author to whom correspondence should be addressed.
Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
DMPC and DOPA were obtained from Avanti Polar Lipids (Alabaster, AL, USA). Full-length ApoE3 was provided by PEPROTECH (Rocky Hill, NJ, USA). DiI was provided by Invitrogen. DiR and Hoechst 33258 were provided by Sigma-Aldrich (St Louis, MO, USA). 4,6-diamidino-2-phenylindole (DAPI) was purchased from Molecular Probes (Eugene, OR, USA).
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