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1 INTRODUCTION Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) requiring dialysis or kidney transplantation worldwide.1-3 Tubulointerstitial fibrosis (TIF) is widely recognized as an essential pathway for the progression of DKD to ESRD and is accompanied by tubular injury and extracellular matrix (ECM) deposition.4, 5 Effective strategies for the treatment of TIF are urgently needed.
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