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Articles by Gard Nelson
S1E61: The UK’s B.1.1.7 Variant — More Contagious and Virulent / Andrew Hayward, Trevor Bedford, Gard Nelson, Graham Medley - Just Human Productions
This winter a new, more contagious variant of SARS-CoV-2 arose in the United Kingdom: B.1.1.7. The CDC estimates that this will become the dominant strain of coronavirus in the United States by March. This is the first of several episodes on the science and policy implications of the new coronavirus variants emerging out of the UK, South Africa, and Brazil.
A recombinant ACE2 Triple Decoy that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants
New Results Shiho Tanaka, Gard Nelson, Anders Olson, Oleksandr Buzko, Wendy Higashide, Annie Shin, Marcos Gonzales, Justin Taft, View ORCID ProfileRoosheel Sandeep Patel, Sofija Buta, Marta Martin-Fernandez, Dusan Sandeep Bogunovic, Patricia R Spilman, Kayvan Niazi, Shahrooz Rabizadeh, View ORCID ProfilePatrick Soon-Shiong doi: https://doi.org/10.1101/2021.03.09.434641 Abstract The highly-transmissible SARS-CoV-2 variants now replacing the first wave strain pose an increased threat to human...
Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 variant) induces conformational change greater than N501Y mutant alone, potentially resulting in an esca…
New Results Gard Nelson, Oleksandr Buzko, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, View ORCID ProfilePatrick Soon-Shiong doi: https://doi.org/10.1101/2021.01.13.426558 Abstract Rapidly spreading SARS-CoV-2 variants present not only an increased threat to human health due to the confirmed greater transmissibility of several of these new strains but, due to conformational changes induced by the mutations, may render first-wave SARS-CoV-2 convalescent sera, vaccine-induced antibodies,...
Millisecond-scale molecular dynamics simulation of spike RBD structure reveals evolutionary adaption of SARS-CoV-2 to stably bind ACE2
New Results Gard Nelson, Oleksandr Buzko, Aaron Bassett, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, View ORCID ProfilePatrick Soon-Shiong doi: https://doi.org/10.1101/2020.12.11.422055 Abstract The Receptor Binding Domain (RBD) of the SARS-CoV-2 surface spike (S) protein interacts with host angiotensin converting enzyme 2 (ACE2) to gain entry to host cells and initiate infection1–3.
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